Assessing the Probability that a Finding Is Genuine for Large-Scale Genetic Association Studies.

Genetic association studies routinely involve massive numbers of statistical tests accompanied by P-values. Whole genome sequencing technologies increased the potential number of tested variants to tens of millions. The more tests are performed, the smaller P-value is required to be deemed significa...

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Bibliographic Details
Main Authors: Chia-Ling Kuo, Olga A Vsevolozhskaya, Dmitri V Zaykin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4425705?pdf=render