Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients

Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients

Abstract Background Recent studies indicate that inflammation may also affect CYP3A4 activity. Associations of CYP3A4-mediated metabolism of quinine, with inflammatory biomarkers were investigated in patients undergoing maintenance hemodialysis (HD). Methods A single dose of 100 mg quinine was given...

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Bibliographic Details
Main Authors: Hadi Molanaei, Abdul Rashid Qureshi, Olof Heimbürger, Bengt Lindholm, Ulf Diczfalusy, Björn Anderstam, Leif Bertilsson, Peter Stenvinkel
Format: Article
Language:English
Published: BMC 2018-06-01
Series:BMC Pharmacology and Toxicology
Subjects:
Inflammation
CYP3A4, hemodialysis
Drug metabolism, quinine
Online Access:http://link.springer.com/article/10.1186/s40360-018-0221-6

Internet

http://link.springer.com/article/10.1186/s40360-018-0221-6

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