Enzalutamide-Resistant Progression of Castration-Resistant Prostate Cancer Is Driven via the JAK2/STAT1-Dependent Pathway

Enzalutamide-Resistant Progression of Castration-Resistant Prostate Cancer Is Driven via the JAK2/STAT1-Dependent Pathway

Previous studies showed that CXCR7 expression was upregulated after enzalutamide (ENZ) treatment, and an increased level of CXCR7 could increase the invasion, migration, and angiogenesis of castration-resistant prostate cancer (CRPC) cells. This study demonstrated that the levels of p-JAK2, p-STAT1,...

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Bibliographic Details
Main Authors: Yong Luo, Xiaobing Yang, Spyridon P. Basourakos, Xuemei Zuo, Dechao Wei, Jiahui Zhao, Mingchuan Li, Qiankun Li, Tao Feng, Pengju Guo, Yongguang Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
castration-resistant prostate cancer
CXCR7
JAK2
STAT1
enzalutamide
resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.652443/full

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https://www.frontiersin.org/articles/10.3389/fmolb.2021.652443/full

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