Brain-Derived Estrogen Regulates Neurogenesis, Learning and Memory with Aging in Female Rats

Although 17β-estradiol (E2) can be locally synthesized in the brain, whether and how brain-derived E2 (BDE2) impacts neurogenesis with aging is largely unclear. In this study, we examined the hippocampal neural stem cells, neurogenesis, and gliogenesis of 1, 3, 6, 14, and 18-month (Mon) female rats....

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Bibliographic Details
Main Authors: Yuanyuan Huang, Wuxiang Sun, Fujia Gao, Haoran Ma, Tao Yuan, Zixuan Liu, Huiyu Liu, Jiewei Hu, Jing Bai, Xin Zhang, Ruimin Wang
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Biology
Subjects:
Online Access:https://www.mdpi.com/2079-7737/12/6/760