The NRF2-p97-NRF2 negative feedback loop

The NRF2-p97-NRF2 negative feedback loop

p97 is a ubiquitin-targeted ATP-dependent segregase that regulates proteostasis, in addition to a variety of other cellular functions. Previously, we demonstrated that p97 negatively regulates NRF2 by extracting ubiquitylated NRF2 from the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex, facilitating pr...

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Bibliographic Details
Main Authors: Aryatara Shakya, Pengfei Liu, Jack Godek, Nicholas W. McKee, Matthew Dodson, Annadurai Anandhan, Aikseng Ooi, Joe G.N. Garcia, Max Costa, Eli Chapman, Donna D. Zhang
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Redox Biology
Subjects:
Nrf2
p97
Oxidative stress
Proteostasis
Cancer
Arsenic
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723002409

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http://www.sciencedirect.com/science/article/pii/S2213231723002409

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