The NRF2-p97-NRF2 negative feedback loop

The NRF2-p97-NRF2 negative feedback loop

p97 is a ubiquitin-targeted ATP-dependent segregase that regulates proteostasis, in addition to a variety of other cellular functions. Previously, we demonstrated that p97 negatively regulates NRF2 by extracting ubiquitylated NRF2 from the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex, facilitating pr...

Full description

Bibliographic Details
Main Authors:	Aryatara Shakya, Pengfei Liu, Jack Godek, Nicholas W. McKee, Matthew Dodson, Annadurai Anandhan, Aikseng Ooi, Joe G.N. Garcia, Max Costa, Eli Chapman, Donna D. Zhang
Format:	Article
Language:	English
Published:	Elsevier 2023-09-01
Series:	Redox Biology
Subjects:	Nrf2 p97 Oxidative stress Proteostasis Cancer Arsenic
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231723002409

Similar Items

Decreased autophagosome biogenesis, reduced NRF2, and enhanced ferroptotic cell death are underlying molecular mechanisms of non-alcoholic fatty liver disease
by: Pengfei Liu, et al.
Published: (2023-02-01)

An NRF2 Perspective on Stem Cells and Ageing
by: Matthew Dodson, et al.
Published: (2021-06-01)

CHML is an NRF2 target gene that regulates mTOR function
by: Matthew Dodson, et al.
Published: (2022-04-01)

Non-canonical NRF2 activation promotes a pro-diabetic shift in hepatic glucose metabolism
by: Pengfei Liu, et al.
Published: (2021-09-01)

The NRF2-LOC344887 signaling axis suppresses pulmonary fibrosis
by: Pengfei Liu, et al.
Published: (2021-01-01)

p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition
by: Senthil K Radhakrishnan, et al.
Published: (2014-01-01)

Nrf1 to the rescue
by: Jin Ye
Published: (2014-01-01)

Inhibitors of the AAA+ Chaperone p97
by: Eli Chapman, et al.
Published: (2015-02-01)

ER-Resident Transcription Factor Nrf1 Regulates Proteasome Expression and Beyond
by: Jun Hamazaki, et al.
Published: (2020-05-01)

Pterostilbene Activates the Nrf2-Dependent Antioxidant Response to Ameliorate Arsenic-Induced Intracellular Damage and Apoptosis in Human Keratinocytes
by: Junfeng Zhou, et al.
Published: (2019-05-01)

New Discoveries and Ambiguities of Nrf2 and ATF3 Signaling in Environmental Arsenic-Induced Carcinogenesis
by: Zhuoyue Bi, et al.
Published: (2021-12-01)

Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence
by: Michael J Steinbaugh, et al.
Published: (2015-07-01)

Mitochondrial ROS, ER Stress, and Nrf2 Crosstalk in the Regulation of Mitochondrial Apoptosis Induced by Arsenite
by: Orazio Cantoni, et al.
Published: (2022-05-01)

The untapped potential of targeting NRF2 in neurodegenerative disease
by: Wei-Tai Chen, et al.
Published: (2023-09-01)

Roles of CNC Transcription Factors NRF1 and NRF2 in Cancer
by: Hiroki Sekine, et al.
Published: (2021-02-01)

NRF2 in Viral Infection
by: Angela Herengt, et al.
Published: (2021-09-01)

Systems biology reveals anatabine to be an NRF2 activator
by: Dimitris E. Messinis, et al.
Published: (2022-11-01)

Arsenic Induces p62 Expression to Form a Positive Feedback Loop with Nrf2 in Human Epidermal Keratinocytes: Implications for Preventing Arsenic-Induced Skin Cancer
by: Palak Shah, et al.
Published: (2017-01-01)

Role of Nrf2 in Pancreatic Cancer
by: Marta Cykowiak, et al.
Published: (2021-12-01)

Distinct Roles of Nrf1 and Nrf2 in Monitoring the Reductive Stress Response to Dithiothreitol (DTT)
by: Reziyamu Wufuer, et al.
Published: (2022-08-01)

NRF2, a Superstar of Ferroptosis
by: Ruihan Yan, et al.
Published: (2023-09-01)

Nrf2 Modulation in Breast Cancer
by: Somayyeh Ghareghomi, et al.
Published: (2022-10-01)

Nrf2 Transcriptional Activity Governs Intestine Development
by: Aleksandra Kopacz, et al.
Published: (2022-05-01)

Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2 Signaling Pathway
by: Chao Li, et al.
Published: (2020-10-01)

NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.
by: Pengfei Liu, et al.
Published: (2020-02-01)

Role of NRF2 in Lung Cancer
by: Miriam Sánchez-Ortega, et al.
Published: (2021-07-01)

Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic Strategies
by: Tahereh Farkhondeh, et al.
Published: (2021-05-01)

An update of Nrf2 activators and inhibitors in cancer prevention/promotion
by: Farhad Pouremamali, et al.
Published: (2022-06-01)

Anti-Osteoarthritis Mechanism of the Nrf2 Signaling Pathway
by: Sarmistha Saha, et al.
Published: (2023-11-01)

Temozolomide Resistance in Glioblastoma by NRF2: Protecting the Evil
by: Karoline Almeida Lima, et al.
Published: (2023-04-01)

Modulation of NRF2/KEAP1 Signaling in Preeclampsia
by: Giovanni Tossetta, et al.
Published: (2023-06-01)

Magnesium Isoglycyrrhizinate Alleviates Arsenic Trioxide-Induced Cardiotoxicity: Contribution of Nrf2 and TLR4/NF-κB Signaling Pathway
by: Zheng B, et al.
Published: (2021-02-01)

The Complex Genetic and Epigenetic Regulation of the Nrf2 Pathways: A Review
by: Joe M. McCord, et al.
Published: (2023-02-01)

The Role of NRF2 in Mycobacterial Infection
by: Masashi Matsuyama, et al.
Published: (2021-11-01)

Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats
by: Liu Y, et al.
Published: (2020-05-01)

Based on Activation of p62-Keap1-Nrf2 Pathway, Hesperidin Protects Arsenic-Trioxide-Induced Cardiotoxicity in Mice
by: Yuxin Jia, et al.
Published: (2021-10-01)

Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases
by: Atena Mansouri, et al.
Published: (2022-02-01)

Flavolignans from Silymarin as Nrf2 Bioactivators and Their Therapeutic Applications
by: Nancy Vargas-Mendoza, et al.
Published: (2020-05-01)

Defining the Functional Targets of Cap‘n’collar Transcription Factors NRF1, NRF2, and NRF3
by: Lara Ibrahim, et al.
Published: (2020-10-01)

Osthole Antagonizes Microglial Activation in an NRF2-Dependent Manner
by: Chuan-Hsiu Liu, et al.
Published: (2023-01-01)