Protocol Optimization for the Production of the Non-Cytotoxic JΔNI5 HSV Vector Deficient in Expression of Immediately Early Genes

Protocol Optimization for the Production of the Non-Cytotoxic JΔNI5 HSV Vector Deficient in Expression of Immediately Early Genes

Non-toxic herpes simplex virus (HSV) vectors can be generated by functional deletion of all immediate-early (IE) genes, providing a benign vehicle with potential for gene therapy. However, deletion of multiple IE genes raises manufacturing concerns and thus limits clinical application of these vecto...

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Bibliographic Details
Main Authors: Seiji Kuroda, Yoshitaka Miyagawa, Yuriko Sato, Motoko Yamamoto, Kumi Adachi, Hiromi Kinoh, William F. Goins, Justus B. Cohen, Joseph C. Glorioso, Nobuhiko Taniai, Hiroshi Yoshida, Takashi Okada
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120300449

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http://www.sciencedirect.com/science/article/pii/S2329050120300449

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