Probing Fast Enantio-Recognition of Drugs with Multiple Chiral Centers by Electrospray-Tandem Mass Spectrometry and Its Mechanism

Probing Fast Enantio-Recognition of Drugs with Multiple Chiral Centers by Electrospray-Tandem Mass Spectrometry and Its Mechanism

Chiral drugs are very complex substances since individual enantiomers may differ in pharmacological and toxic effects, making it necessary to analyze enantiomers separately. In this study, we investigated the chiral differentiation of two ezetimibe enantiomers (i.e., <i>SRS</i>-EZM and &...

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Bibliographic Details
Main Authors: Hechen Wang, Xiaolei Chen, Yali Wang, Lu Wang, Zhangzhao Gao, Haihong Hu, Lushan Yu, Su Zeng, Yu Kang
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Applied Sciences
Subjects:
chiral drug
ESI
MS/MS
enantiomer
recognition
multiple chiral centers
Online Access:https://www.mdpi.com/2076-3417/12/20/10353

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https://www.mdpi.com/2076-3417/12/20/10353

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