Diversity-Oriented Synthesis Catalyzed by Diethylaminosulfur-Trifluoride—Preparation of New Antitumor Ecdysteroid Derivatives

Diversity-Oriented Synthesis Catalyzed by Diethylaminosulfur-Trifluoride—Preparation of New Antitumor Ecdysteroid Derivatives

Fluorine represents a privileged building block in pharmaceutical chemistry. Diethylaminosulfur-trifluoride (DAST) is a reagent commonly used for replacement of alcoholic hydroxyl groups with fluorine and is also known to catalyze water elimination and cyclic Beckmann-rearrangement type reactions. I...

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Bibliographic Details
Main Authors: Máté Vágvölgyi, Endre Kocsis, Márta Nové, Nikoletta Szemerédi, Gabriella Spengler, Zoltán Kele, Róbert Berkecz, Tamás Gáti, Gábor Tóth, Attila Hunyadi
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
DAST
semi-synthesis
fluorination
Beckmann-rearrangement
cyclopropane
natural product
Online Access:https://www.mdpi.com/1422-0067/23/7/3447

Internet

https://www.mdpi.com/1422-0067/23/7/3447

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