Supercritical fluid chromatographic chiral separation of potential P2RX7 antagonists containing one, two and three chiral centers
Eleven polysaccharide-based chiral stationary phases were screened to separate stereoisomers of six lactam derivatives by supercritical fluid chromatography (SFC). Those molecules are antagonists of the P2×7 receptor with potential anti-inflammatory activity. They present a mixture of either two ena...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2024-05-01
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Series: | Journal of Chromatography Open |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2772391724000161 |