Endothelial PDGF-BB/PDGFR-β signaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation

Endothelial PDGF-BB/PDGFR-β signaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation

Abstract The mechanisms that coordinate the shift from joint homeostasis to osteoarthritis (OA) remain unknown. No pharmacological intervention can currently prevent the progression of osteoarthritis. Accumulating evidence has shown that subchondral bone deterioration is a primary trigger for overly...

Full description

Bibliographic Details
Main Authors: Zhuang Cui, Hangtian Wu, Ye Xiao, Ting Xu, Junjie Jia, Hancheng Lin, Rongmin Lin, Kun Chen, Yihuang Lin, Kaiqun Li, Xiaohu Wu, Changjun Li, Bin Yu
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-022-00229-6

Internet

https://doi.org/10.1038/s41413-022-00229-6

Similar Items