Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation

Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation

Abstract Background Testosterone contributes to male organism development, such as bone density, muscle development, and fat repartition. Estrogen (derived from testosterone) also contributes to female reproductive system development. Here, we investigated the effect of testosterone on glioma cells...

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Bibliographic Details
Main Authors: Kouminin Kanwore, Konimpo Kanwore, Xiaoxiao Guo, Ying Xia, Han Zhou, Lin Zhang, Gabriel Komla Adzika, Adu-Amankwaah Joseph, Ayanlaja Abdulrahman Abiola, Peipei Mu, Piniel Alphayo Kambey, Marie Louis N’dzie Noah, DianShuai Gao
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Inflammation and Regeneration
Subjects:
Glioma
Testosterone
GDNF
Cyclophilin A
Neuroprotection
Neuroinflammation
Online Access:https://doi.org/10.1186/s41232-023-00300-7

Internet

https://doi.org/10.1186/s41232-023-00300-7

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