Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation

Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation

Abstract Background Testosterone contributes to male organism development, such as bone density, muscle development, and fat repartition. Estrogen (derived from testosterone) also contributes to female reproductive system development. Here, we investigated the effect of testosterone on glioma cells...

Full description

Bibliographic Details
Main Authors:	Kouminin Kanwore, Konimpo Kanwore, Xiaoxiao Guo, Ying Xia, Han Zhou, Lin Zhang, Gabriel Komla Adzika, Adu-Amankwaah Joseph, Ayanlaja Abdulrahman Abiola, Peipei Mu, Piniel Alphayo Kambey, Marie Louis N’dzie Noah, DianShuai Gao
Format:	Article
Language:	English
Published:	BMC 2023-10-01
Series:	Inflammation and Regeneration
Subjects:	Glioma Testosterone GDNF Cyclophilin A Neuroprotection Neuroinflammation
Online Access:	https://doi.org/10.1186/s41232-023-00300-7

Similar Items

Failure of Glial Cell-Line Derived Neurotrophic Factor (GDNF) in Clinical Trials Orchestrated By Reduced NR4A2 (NURR1) Transcription Factor in Parkinson’s Disease. A Systematic Review
by: Piniel Alphayo Kambey, et al.
Published: (2021-02-01)

Extracellular and Intracellular Factors in Brain Cancer
by: Kouminin Kanwore, et al.
Published: (2021-08-01)

Doublecortin undergo nucleocytoplasmic transport via the RanGTPase signaling to promote glioma progression
by: Abiola Abdulrahman Ayanlaja, et al.
Published: (2020-02-01)

Postresuscitation Changes in the Expression of GlialDerived Neurotrophic Factor (GDNF): Association with Cerebellar Purkinje Cell Damage (An experimental study)
by: M. Sh. Avrushchenko, et al.
Published: (2014-10-01)

The Role of Metals in the Neuroregenerative Action of BDNF, GDNF, NGF and Other Neurotrophic Factors
by: Vincenzo Giuseppe Nicoletti, et al.
Published: (2022-07-01)

Low Levels of Adenosine and GDNF Are Potential Risk Factors for Parkinson’s Disease with Sleep Disorders
by: Li Wang, et al.
Published: (2023-01-01)

Gray matter volume reduction in orbitofrontal cortex correlated with plasma glial cell line-derived neurotrophic factor (GDNF) levels within major depressive disorder
by: Yifan Wu, et al.
Published: (2023-01-01)

Single-nuclei RNA sequencing uncovers heterogenous transcriptional signatures in Parkinson’s disease associated with nuclear receptor-related factor 1 defect
by: Piniel Alphayo Kambey, et al.
Published: (2023-01-01)

Mechanism of methylation and acetylation of high GDNF transcription in glioma cells: A review
by: Lin Zhang, et al.
Published: (2019-06-01)

Lower GDNF Serum Level Is a Possible Risk Factor for Constipation in Patients With Parkinson Disease: A Case–Control Study
by: Gang Chen, et al.
Published: (2022-01-01)

Biology of GDNF and its receptors — Relevance for disorders of the central nervous system
by: Carlos F. Ibáñez, et al.
Published: (2017-01-01)

Intestinal Epithelial Barrier Maturation by Enteric Glial Cells Is GDNF-Dependent
by: Michael Meir, et al.
Published: (2021-02-01)

A possible role of GDNF expression by which cabergoline use affects corpus callosum
by: Georgios Mitsiakos, et al.
Published: (2018-12-01)

Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain
by: Lars U. Wahlberg, et al.
Published: (2020-04-01)

Cistanche tubulosa Protects Dopaminergic Neurons through Regulation of Appotosis and Glial Cell-derived Neurotrophic Factor: in Vivo and in Vitro
by: Qian Xu, et al.
Published: (2016-12-01)

Estrogen downregulates CD73/adenosine axis hyperactivity via adaptive modulation PI3K/Akt signaling to prevent myocarditis and arrhythmias during chronic catecholamines stress
by: Marie Louise Ndzie Noah, et al.
Published: (2023-02-01)

GDNF Increases Inhibitory Synaptic Drive on Principal Neurons in the Hippocampus via Activation of the Ret Pathway
by: Apostolos Mikroulis, et al.
Published: (2022-10-01)

Study of GDNF-Family Receptor Alpha 2 And Inhibitory Activity of GDNF-Family Receptor Alpha 2b (GFRα2b) Isoform
by: Yoong, Li Foong, et al.
Published: (2005)

GDNF and the RET Receptor in Cancer: New Insights and Therapeutic Potential
by: Lois M. Mulligan
Published: (2019-01-01)

MiRNAs Mediate GDNF-Induced Proliferation and Migration of Glioma Cells
by: Bao-Le Zhang, et al.
Published: (2017-12-01)

GDNF protects enteric glia from apoptosis: evidence for an autocrine loop
by: Steinkamp Martin, et al.
Published: (2012-01-01)

Reawakening GDNF's regenerative past in mice and humans
by: Andres Samos, et al.
Published: (2022-06-01)

The Influence of Neurotrophic Factors BDNF and GDNF Overexpression on the Functional State of Mice and Their Adaptation to Audiogenic Seizures
by: Angelina O. Kustova, et al.
Published: (2022-08-01)

Opposing Spatially Segregated Function of Endogenous GDNF-RET Signaling in Cocaine Addiction
by: Daniel R. Garton, et al.
Published: (2023-04-01)

Schwann cells migrate along axons in the absence of GDNF signaling
by: Heermann Stephan, et al.
Published: (2012-08-01)

Combination therapy using GDNF and cell transplant in Parkinson’s disease
by: Bin Xiao, et al.
Published: (2022-07-01)

Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF
by: M.E. Emborg, et al.
Published: (2009-11-01)

Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits
by: Soledad Marton, et al.
Published: (2019-03-01)

TGF-β1 Increases GDNF Production by Upregulating the Expression of GDNF and Furin in Human Granulosa-Lutein Cells
by: Jingwen Yin, et al.
Published: (2020-01-01)

3D-printed hyaluronic acid hydrogel scaffolds impregnated with neurotrophic factors (BDNF, GDNF) for post-traumatic brain tissue reconstruction
by: Tatiana A. Mishchenko, et al.
Published: (2022-08-01)

Endogenous GDNF Is Unable to Halt Dopaminergic Injury Triggered by Microglial Activation
by: Julieta Mendes-Oliveira, et al.
Published: (2023-12-01)

How to Build and to Protect the Neuromuscular Junction: The Role of the Glial Cell Line-Derived Neurotrophic Factor
by: Serena Stanga, et al.
Published: (2020-12-01)

Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease
by: Anna-Maija Penttinen, et al.
Published: (2018-06-01)

Suicide and Neurotrophin Factors: A Systematic Review of the Correlation between BDNF and GDNF and Self-Killing
by: Stefania De Simone, et al.
Published: (2022-12-01)

miR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons
by: Anna-Elisa Roser, et al.
Published: (2018-06-01)

Glial cell line-derived neurotrophic factor and antioxidants preserve the electrical responsiveness of the spiral ganglion neurons after experimentally induced deafness
by: Jun Maruyama, et al.
Published: (2008-01-01)

Analysis of Acute and Chronic Methamphetamine Treatment in Mice on Gdnf System Expression Reveals a Potential Mechanism of Schizophrenia Susceptibility
by: Laoise Casserly, et al.
Published: (2023-09-01)

Ultrasound-Triggered Effects of the Microbubbles Coupled to GDNF Plasmid-Loaded PEGylated Liposomes in a Rat Model of Parkinson's Disease
by: Peijian Yue, et al.
Published: (2018-04-01)

Selective injury to dopaminergic neurons up-regulates GDNF in substantia nigra postnatal cell cultures: Role of neuron–glia crosstalk
by: Ana Saavedra, et al.
Published: (2006-09-01)

Oxidative stress induced by sustained supraphysiological intrastriatal GDNF delivery is prevented by dose regulation
by: Marcelo Duarte Azevedo, et al.
Published: (2023-12-01)