Modifying PCDH19 levels affects cortical interneuron migration

Modifying PCDH19 levels affects cortical interneuron migration

PCDH19 is a transmembrane protein and member of the protocadherin family. It is encoded by the X-chromosome and more than 200 mutations have been linked to the neurodevelopmental PCDH-clustering epilepsy (PCDH19-CE) syndrome. A disturbed cell-cell contact that arises when random X-inactivation creat...

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Bibliographic Details
Main Authors: Anna Pancho, Manuela D. Mitsogiannis, Tania Aerts, Marco Dalla Vecchia, Lena K. Ebert, Lieve Geenen, Lut Noterdaeme, Ria Vanlaer, Anne Stulens, Paco Hulpiau, Katrien Staes, Frans Van Roy, Peter Dedecker, Bernhard Schermer, Eve Seuntjens
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Neuroscience
Subjects:
interneuron
medial ganglionic eminence
PCDH19-CE
neuronal migration
brain development
neurodevelopmental disorder
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.887478/full

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https://www.frontiersin.org/articles/10.3389/fnins.2022.887478/full

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