Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension

Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension

Summary: Persistent liver injury triggers a fibrogenic program that causes pathologic remodeling of the hepatic microenvironment (i.e., liver fibrosis) and portal hypertension. The dynamics of gene regulation during liver disease progression and early regression remain understudied. Here, we generat...

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Main Authors: Oleksandr Petrenko, Philipp Königshofer, Ksenia Brusilovskaya, Benedikt S. Hofer, Katharina Bareiner, Benedikt Simbrunner, Frank Jühling, Thomas F. Baumert, Joachim Lupberger, Michael Trauner, Stefan G. Kauschke, Larissa Pfisterer, Eric Simon, André F. Rendeiro, Laura P.M.H. de Rooij, Philipp Schwabl, Thomas Reiberger
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:iScience
Subjects:
Disease
Fibrosis
Integrative aspects of cell biology
Model organism
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224005224

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http://www.sciencedirect.com/science/article/pii/S2589004224005224

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