CLEC18A Impairs Phagocytosis by Reducing FcγRIIA Expression and Arresting Autophagosome-Lysosome Fusion

CLEC18A Impairs Phagocytosis by Reducing FcγRIIA Expression and Arresting Autophagosome-Lysosome Fusion

ABSTRACT Mixed cryoglobulinemia (MC) is a hepatitis C virus (HCV)–related extrahepatic manifestation that is characterized by the abnormal presence of immune complexes (ICs). This may be due to the reduced uptake and clearance of ICs. The C-type lectin member 18A (CLEC18A) is a secretory protein tha...

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Bibliographic Details
Main Authors: Tsai-Ling Liao, Yi-Ming Chen, Kuo-Tung Tang, Ying-Ying Yang, Der-Yuan Chen, Tsung-Hsien Chan, Hui-Ju Tsai, Shie-Liang Hsieh
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
C-type lectin 18A
hepatitis C virus
mixed cryoglobulinemia
FcγRIIA
Rab7
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02903-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02903-22

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