Multifunctional hydrogel targeting senescence to accelerate diabetic wound healing through promoting angiogenesis

Multifunctional hydrogel targeting senescence to accelerate diabetic wound healing through promoting angiogenesis

Abstract Diabetic wound healing remains a significant clinical challenge because of hyperglycaemia-induced cellular senescence, impaired angiogenesis, and chronic inflammation. To address these issues, we developed a multifunctional hydrogel (GelMA/PNS/Alg@IGF-1) that integrates gelatine methacryloy...

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Bibliographic Details
Main Authors: Hao Yang, Yongfei Chen, Yanchao Rong, Yuxi Zhou, Shuting Li, Xiaohui Li, Honglin Wu, Dongming Lv, Xiaoling Cao, Peng Wang, Jiayuan Zhu, Bing Tang, Zhicheng Hu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Nanobiotechnology
Subjects:
Diabetic wound healing
Panax Notoginseng saponins
Insulin-like growth factor-1
Gelatine methacryloyl hydrogel
Sodium alginate microspheres
Online Access:https://doi.org/10.1186/s12951-025-03274-5

Internet

https://doi.org/10.1186/s12951-025-03274-5

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