The Role of Epigenetic Change in Therapy-Induced Neuroendocrine Prostate Cancer Lineage Plasticity

The Role of Epigenetic Change in Therapy-Induced Neuroendocrine Prostate Cancer Lineage Plasticity

The androgen receptor (AR) signaling pathway is critical for growth and differentiation of prostate cancer cells. For that reason, androgen deprivation therapy with medical or surgical castration is the principal treatment for metastatic prostate cancer. More recently, new potent AR signaling inhibi...

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Bibliographic Details
Main Authors: William K. Storck, Allison M. May, Thomas C. Westbrook, Zhi Duan, Colm Morrissey, Joel A. Yates, Joshi J. Alumkal
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Endocrinology
Subjects:
Neuroendocrine prostate cancer (NEPC)
Lineage plasticity
transdifferentiation
Androgen Receptor (AR)
epigenetics
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.926585/full

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https://www.frontiersin.org/articles/10.3389/fendo.2022.926585/full

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