Responsiveness to basement membrane extract as a possible trait for tumorigenicity characterization

Immortalized cell lines used to produce vaccines are expected to be described in terms of their tumorigenicity. However, current in vivo tumorigenicity assays can be time-consuming and results can be equivocal, especially for weakly tumorigenic cells. Basement membrane extract (BME) derived from the...

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Bibliographic Details
Main Authors: Haruhiko Murata, Romelda Omeir, Wei Tu, Lynda Lanning, Kathryn Phy, Gideon Foseh, Andrew M. Lewis, Jr., Keith Peden
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Vaccine: X
Online Access:http://www.sciencedirect.com/science/article/pii/S2590136219300014