Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants

Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants

Summary: Genome-wide association studies (GWASs) have successfully identified 145 genomic regions that contribute to schizophrenia risk, but linkage disequilibrium makes it challenging to discern causal variants. We performed a massively parallel reporter assay (MPRA) on 5,173 fine-mapped schizophre...

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Bibliographic Details
Main Authors: Jessica C. McAfee, Sool Lee, Jiseok Lee, Jessica L. Bell, Oleh Krupa, Jessica Davis, Kimberly Insigne, Marielle L. Bond, Nanxiang Zhao, Alan P. Boyle, Douglas H. Phanstiel, Michael I. Love, Jason L. Stein, W. Brad Ruzicka, Jose Davila-Velderrain, Sriram Kosuri, Hyejung Won
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Cell Genomics
Subjects:
MPRA
schizophrenia
GWAS
non-coding variants
accessibility-by-contact model
variant function
Online Access:http://www.sciencedirect.com/science/article/pii/S2666979X23002185

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http://www.sciencedirect.com/science/article/pii/S2666979X23002185

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