Parkin deficiency exacerbates fasting-induced skeletal muscle wasting in mice

Abstract Parkinson’s Disease (PD) is a chronic and progressive neurodegenerative disease manifesting itself with tremors, muscle stiffness, bradykinesia, dementia, and depression. Mutations of mitochondrial E3 ligase, PARKIN, have been associated with juvenile PD. Previous studies have characterized...

Full description

Bibliographic Details
Main Authors: Nesibe Peker, Mridula Sharma, Ravi Kambadur
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-022-00419-3