A Gut Reaction to SIV and SHIV Infection: Lower Dysregulation of Mucosal T Cells during Acute Infection Is Associated with Greater Viral Suppression during cART

A Gut Reaction to SIV and SHIV Infection: Lower Dysregulation of Mucosal T Cells during Acute Infection Is Associated with Greater Viral Suppression during cART

Selection of a pre-clinical non-human primate (NHP) model is essential when evaluating therapeutic vaccine and treatment strategies for HIV. SIV and SHIV-infected NHPs exhibit a range of viral burdens, pathologies, and responses to combinatorial antiretroviral therapy (cART) regimens and the choice...

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Bibliographic Details
Main Authors: Megan A. O’Connor, Paul V. Munson, Sandra E. Dross, Hillary C. Tunggal, Thomas B. Lewis, Jessica Osborn, Christopher W. Peterson, Meei-Li W. Huang, Cassandra Moats, Jeremy Smedley, Keith R. Jerome, Hans-Peter Kiem, Kenneth C. Bagley, James I. Mullins, Deborah Heydenburg Fuller
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Viruses
Subjects:
non-human primate (NHP)
SHIV
SIV
cART
colon
T helper 17 (Th17)
Online Access:https://www.mdpi.com/1999-4915/13/8/1609

Internet

https://www.mdpi.com/1999-4915/13/8/1609

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