The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing.

The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing.

Dengue virus NS5 protein plays multiple functions in the cytoplasm of infected cells, enabling viral RNA replication and counteracting host antiviral responses. Here, we demonstrate a novel function of NS5 in the nucleus where it interferes with cellular splicing. Using global proteomic analysis of...

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Bibliographic Details
Main Authors: Federico A De Maio, Guillermo Risso, Nestor G Iglesias, Priya Shah, Berta Pozzi, Leopoldo G Gebhard, Pablo Mammi, Estefania Mancini, Marcelo J Yanovsky, Raul Andino, Nevan Krogan, Anabella Srebrow, Andrea V Gamarnik
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5004807?pdf=render

Internet

http://europepmc.org/articles/PMC5004807?pdf=render

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