Defining function of wild-type and three patient-specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma

Defining function of wild-type and three patient-specific TP53 mutations in a zebrafish model of embryonal rhabdomyosarcoma

In embryonal rhabdomyosarcoma (ERMS) and generally in sarcomas, the role of wild-type and loss- or gain-of-function TP53 mutations remains largely undefined. Eliminating mutant or restoring wild-type p53 is challenging; nevertheless, understanding p53 variant effects on tumorigenesis remains central...

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Bibliographic Details
Main Authors: Jiangfei Chen, Kunal Baxi, Amanda E Lipsitt, Nicole Rae Hensch, Long Wang, Prethish Sreenivas, Paulomi Modi, Xiang Ru Zhao, Antoine Baudin, Daniel G Robledo, Abhik Bandyopadhyay, Aaron Sugalski, Anil K Challa, Dias Kurmashev, Andrea R Gilbert, Gail E Tomlinson, Peter Houghton, Yidong Chen, Madeline N Hayes, Eleanor Y Chen, David S Libich, Myron S Ignatius
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-06-01
Series:eLife
Subjects:
zebrafish
TP53
rhabdomyosarcoma
tumor initiation
mutant tp53
rare varients
Online Access:https://elifesciences.org/articles/68221

Internet

https://elifesciences.org/articles/68221

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