p53 and HuR combinatorially control the biphasic dynamics of microRNA-125b in response to genotoxic stress
miRNA-125b, a translational repressor of p53, undergoes initial HuR-mediated exosomal export in response to DNA damage, leading to p53 upregulation, which in turn induces transcription and processing of miR-125b causing inhibition of p53 expression.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-04507-9 |