p53 and HuR combinatorially control the biphasic dynamics of microRNA-125b in response to genotoxic stress
miRNA-125b, a translational repressor of p53, undergoes initial HuR-mediated exosomal export in response to DNA damage, leading to p53 upregulation, which in turn induces transcription and processing of miR-125b causing inhibition of p53 expression.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-023-04507-9 |
| _version_ | 1811175756602015744 |
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| author | Binita Goswami Deepika Ahuja David Pastré Partho Sarothi Ray |
| author_facet | Binita Goswami Deepika Ahuja David Pastré Partho Sarothi Ray |
| author_sort | Binita Goswami |
| collection | DOAJ |
| description | miRNA-125b, a translational repressor of p53, undergoes initial HuR-mediated exosomal export in response to DNA damage, leading to p53 upregulation, which in turn induces transcription and processing of miR-125b causing inhibition of p53 expression. |
| first_indexed | 2024-04-10T19:41:04Z |
| format | Article |
| id | doaj.art-869cf634c6594ff2bdee8f116d8a0bc9 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-10T19:41:04Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-869cf634c6594ff2bdee8f116d8a0bc92023-01-29T12:19:36ZengNature PortfolioCommunications Biology2399-36422023-01-016111710.1038/s42003-023-04507-9p53 and HuR combinatorially control the biphasic dynamics of microRNA-125b in response to genotoxic stressBinita Goswami0Deepika Ahuja1David Pastré2Partho Sarothi Ray3Department of Biological Sciences, Indian Institute of Science Education and Research, Kolkata, MohanpurDepartment of Biological Sciences, Indian Institute of Science Education and Research, Kolkata, MohanpurSABNP, Univ Evry, INSERM U1204, Université Paris-SaclayDepartment of Biological Sciences, Indian Institute of Science Education and Research, Kolkata, MohanpurmiRNA-125b, a translational repressor of p53, undergoes initial HuR-mediated exosomal export in response to DNA damage, leading to p53 upregulation, which in turn induces transcription and processing of miR-125b causing inhibition of p53 expression.https://doi.org/10.1038/s42003-023-04507-9 |
| spellingShingle | Binita Goswami Deepika Ahuja David Pastré Partho Sarothi Ray p53 and HuR combinatorially control the biphasic dynamics of microRNA-125b in response to genotoxic stress Communications Biology |
| title | p53 and HuR combinatorially control the biphasic dynamics of microRNA-125b in response to genotoxic stress |
| title_full | p53 and HuR combinatorially control the biphasic dynamics of microRNA-125b in response to genotoxic stress |
| title_fullStr | p53 and HuR combinatorially control the biphasic dynamics of microRNA-125b in response to genotoxic stress |
| title_full_unstemmed | p53 and HuR combinatorially control the biphasic dynamics of microRNA-125b in response to genotoxic stress |
| title_short | p53 and HuR combinatorially control the biphasic dynamics of microRNA-125b in response to genotoxic stress |
| title_sort | p53 and hur combinatorially control the biphasic dynamics of microrna 125b in response to genotoxic stress |
| url | https://doi.org/10.1038/s42003-023-04507-9 |
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