Mechanistic Studies and a Retrospective Cohort Study: The Interaction between PPAR Agonists and Immunomodulatory Agents in Multiple Myeloma

Mechanistic Studies and a Retrospective Cohort Study: The Interaction between PPAR Agonists and Immunomodulatory Agents in Multiple Myeloma

Our previous study demonstrated that peroxisome proliferator-activated receptor (PPAR) agonists downregulated cereblon (CRBN) expression and reduced the anti-myeloma activity of lenalidomide in vitro and in vivo. We aimed to determine whether DNA methylation and protein degradation contribute to the...

Full description

Bibliographic Details
Main Authors: Jian Wu, Emily Chu, Barry Paul, Yubin Kang
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
immunomodulatory drugs
PPAR
diabetes
dyslipidemia
CpG island
methylation
Online Access:https://www.mdpi.com/2072-6694/14/21/5272

Internet

https://www.mdpi.com/2072-6694/14/21/5272

Similar Items