Flap Endonuclease 1 Endonucleolytically Processes RNA to Resolve R-Loops through DNA Base Excision Repair

Flap Endonuclease 1 Endonucleolytically Processes RNA to Resolve R-Loops through DNA Base Excision Repair

Flap endonuclease 1 (FEN1) is an essential enzyme that removes RNA primers and base lesions during DNA lagging strand maturation and long-patch base excision repair (BER). It plays a crucial role in maintaining genome stability and integrity. FEN1 is also implicated in RNA processing and biogenesis....

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Bibliographic Details
Main Authors: Eduardo E. Laverde, Aris A. Polyzos, Pawlos P. Tsegay, Mohammad Shaver, Joshua D. Hutcheson, Lata Balakrishnan, Cynthia T. McMurray, Yuan Liu
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Genes
Subjects:
flap endonuclease 1 (FEN1)
R-loop
base excision repair (BER)
Online Access:https://www.mdpi.com/2073-4425/14/1/98

Internet

https://www.mdpi.com/2073-4425/14/1/98

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