Bax/Tubulin/Epithelial-Mesenchymal Pathways Determine the Efficacy of Silybin Analog HM015k in Colorectal Cancer Cell Growth and Metastasis

Bax/Tubulin/Epithelial-Mesenchymal Pathways Determine the Efficacy of Silybin Analog HM015k in Colorectal Cancer Cell Growth and Metastasis

The inhibition of apoptosis, disruption of cellular microtubule dynamics, and over-activation of the epithelial mesenchymal transition (EMT), are involved in the progression, metastasis, and resistance of colorectal cancer (CRC) to chemotherapy. Therefore, the design of a molecule that can target th...

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Bibliographic Details
Main Authors: Haneen Amawi, Noor A. Hussein, Charles R. Ashby, Rawan Alnafisah, Leticia M. Sanglard, Elangovan Manivannan, Chandrabose Karthikeyan, Piyush Trivedi, Kathryn M. Eisenmann, Robert W. Robey, Amit K. Tiwari
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Pharmacology
Subjects:
silybin
colorectal cancer
tubulin inhibition
metastasis
epithelial-mesenchymal-transition
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00520/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00520/full

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