Pivotal Role of Fatty Acid Synthase in c-MYC Driven Hepatocarcinogenesis

Pivotal Role of Fatty Acid Synthase in c-MYC Driven Hepatocarcinogenesis

Hepatocellular carcinoma (HCC) is a deadly form of liver malignancy with limited treatment options. Amplification and/or overexpression of <i>c-MYC</i> is one of the most frequent genetic events in human HCC. The mammalian target of Rapamycin Complex 1 (mTORC1) is a major functional axis...

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Bibliographic Details
Main Authors: Jiaoyuan Jia, Li Che, Antonio Cigliano, Xue Wang, Graziella Peitta, Junyan Tao, Sheng Zhong, Silvia Ribback, Matthias Evert, Xin Chen, Diego F. Calvisi
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
FASN
lipogenesis
hepatocellular carcinoma
c-Myc
mouse models
Online Access:https://www.mdpi.com/1422-0067/21/22/8467

Internet

https://www.mdpi.com/1422-0067/21/22/8467

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