Dynamic Phenomena and Complexation Effects in the α-Lithiation and Asymmetric Functionalization of Azetidines

Dynamic Phenomena and Complexation Effects in the α-Lithiation and Asymmetric Functionalization of Azetidines

In this work it is demonstrated that enantiomerically enriched <i>N</i>-alkyl 2-oxazolinylazetidines undergo exclusive α-lithiation, and that the resulting lithiated intermediate is chemically stable but configurationally labile under the given experimental conditions that afford enantio...

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Bibliographic Details
Main Authors: Pantaleo Musci, Marco Colella, Angela Altomare, Giuseppe Romanazzi, Nadeem S. Sheikh, Leonardo Degennaro, Renzo Luisi
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Molecules
Subjects:
azetidines
organolithiums
nitrogen dynamics
heterocyclic chemistry
computational chemistry
Online Access:https://www.mdpi.com/1420-3049/27/9/2847

Internet

https://www.mdpi.com/1420-3049/27/9/2847

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