Passive Transfer of Animal-Derived Polyclonal Hyperimmune Antibodies Provides Protection of Mice from Lethal Lassa Virus Infection

Passive Transfer of Animal-Derived Polyclonal Hyperimmune Antibodies Provides Protection of Mice from Lethal Lassa Virus Infection

Background: Lassa virus (LASV) can cause severe acute systemic infection in humans. No approved antiviral drugs or vaccines are currently available. Antibody-based therapeutics are considered a promising treatment strategy in the management of LASV disease. Methods: We used chimeric Ifnar<sup>...

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Bibliographic Details
Main Authors: Lisa Oestereich, Helena Müller-Kräuter, Elisa Pallasch, Thomas Strecker
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Viruses
Subjects:
Lassa mammarenavirus
Lassa fever
arenavirus
virus-like particle
neutralizing antibodies
in vivo protection
Online Access:https://www.mdpi.com/1999-4915/15/7/1436

Internet

https://www.mdpi.com/1999-4915/15/7/1436

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