Succinate-induced macrophage polarization and RBP4 secretion promote vascular sprouting in ocular neovascularization

Succinate-induced macrophage polarization and RBP4 secretion promote vascular sprouting in ocular neovascularization

Abstract Pathological neovascularization is a pivotal biological process in wet age-related macular degeneration (AMD), retinopathy of prematurity (ROP) and proliferative diabetic retinopathy (PDR), in which macrophages (Mφs) play a key role. Tip cell specialization is critical in angiogenesis; howe...

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Bibliographic Details
Main Authors: Tianyi Shen, Ruoyi Lin, Chengyu Hu, Donghui Yu, Chengda Ren, Tingting Li, Meijiang Zhu, Zhongqi Wan, Tu Su, Yan Wu, Wenting Cai, Jing Yu
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Neuroinflammation
Subjects:
Choroidal neovascularization
Macrophage
Oxygen-induced retinopathy
Succinate
Tip cells
Online Access:https://doi.org/10.1186/s12974-023-02998-1

Internet

https://doi.org/10.1186/s12974-023-02998-1

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