Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice

Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice

Increasing evidence indicates the involvement of myocardial oxidative injury and mitochondrial dysfunction in the pathophysiology of heart failure (HF). Alpha-ketoglutarate (AKG) is an intermediate metabolite of the tricarboxylic acid (TCA) cycle that participates in different cellular metabolic and...

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Bibliographic Details
Main Authors: Dongqi An, Qingchun Zeng, Peijian Zhang, Zhuang Ma, Hao Zhang, Zuheng Liu, Jiaying Li, Hao Ren, Dingli Xu
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Redox Biology
Subjects:
Alpha-ketoglutarate
Mitophagy
Transverse aortic constriction
Myocardial hypertrophy
Cardiac insufficiency
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721002470

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http://www.sciencedirect.com/science/article/pii/S2213231721002470

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