Synthesis and anticancer activity of new quinazoline derivatives

In this study, a new series of quinazoline derivatives (3–26) was synthesized and characterized via physicochemical and spectral means. Treatment of 2-amino-5-methylbenzoic acid with butyl isothiocyanate resulted in the new 2-thioxoquinazolin-4-one (3). Alkylation and hydrazinolysis of the inherent...

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Bibliographic Details
Main Authors: Hatem A. Abuelizz, Mohamed Marzouk, Hazem Ghabbour, Rashad Al-Salahi
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Saudi Pharmaceutical Journal
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016417300865