Exosomal CagA from Helicobacter pylori aggravates intestinal epithelium barrier dysfunction in chronic colitis by facilitating Claudin-2 expression

Exosomal CagA from Helicobacter pylori aggravates intestinal epithelium barrier dysfunction in chronic colitis by facilitating Claudin-2 expression

Abstract Background The chronic infection with Helicobacter pylori (H. pylori), especially cytotoxin-associated gene A-positive (CagA+) strains, has been associated with various extragastric disorders. Evaluating the potential impacts of virulence factor CagA on intestine may provide a better unders...

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Bibliographic Details
Main Authors: Yinjie Guo, Canxia Xu, Renjie Gong, Tingzi Hu, Xue Zhang, Xiaoran Xie, Jingshu Chi, Huan Li, Xiujuan Xia, Xiaoming Liu
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Gut Pathogens
Subjects:
CagA
Exosome
Colitis
Tight junction
Claudin-2
CDX2
Online Access:https://doi.org/10.1186/s13099-022-00486-0

Internet

https://doi.org/10.1186/s13099-022-00486-0

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