Activation and Identification of a Griseusin Cluster in <i>Streptomyces</i> sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods

Activation and Identification of a Griseusin Cluster in <i>Streptomyces</i> sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods

<i>Streptomyces</i> are well-known producers of a range of different secondary metabolites, including antibiotics and other bioactive compounds. Recently, it has been demonstrated that “silent” biosynthetic gene clusters (BGCs) can be activated by heterologously expressing transcriptiona...

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Bibliographic Details
Main Authors: Charlotte Beck, Tetiana Gren, Francisco Javier Ortiz-López, Tue Sparholt Jørgensen, Daniel Carretero-Molina, Jesús Martín Serrano, José R. Tormo, Daniel Oves-Costales, Eftychia E. Kontou, Omkar S. Mohite, Erik Mingyar, Evi Stegmann, Olga Genilloud, Tilmann Weber
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Molecules
Subjects:
transcriptional regulators
biosynthetic gene cluster
genome mining
heterologous expression
griseusin
pyranonaphtoquinone
Online Access:https://www.mdpi.com/1420-3049/26/21/6580

Internet

https://www.mdpi.com/1420-3049/26/21/6580

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