A crosstalk between hepcidin and IRE/IRP pathways controls ferroportin expression and determines serum iron levels in mice

A crosstalk between hepcidin and IRE/IRP pathways controls ferroportin expression and determines serum iron levels in mice

The iron hormone hepcidin is transcriptionally activated by iron or inflammation via distinct, partially overlapping pathways. We addressed how iron affects inflammatory hepcidin levels and the ensuing hypoferremic response. Dietary iron overload did not mitigate hepcidin induction in lipopolysaccha...

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Bibliographic Details
Main Authors: Edouard Charlebois, Carine Fillebeen, Angeliki Katsarou, Aleksandr Rabinovich, Kazimierz Wisniewski, Vivek Venkataramani, Bernhard Michalke, Anastasia Velentza, Kostas Pantopoulos
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-09-01
Series:eLife
Subjects:
iron metabolism
inflammation
hepcidin
Online Access:https://elifesciences.org/articles/81332

Internet

https://elifesciences.org/articles/81332

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