Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial

Mechanistically informed non-invasive peripheral nerve stimulation for peripheral neuropathic pain: a randomised double-blind sham-controlled trial

Abstract Background Induction of long-term synaptic depression (LTD) is proposed as a treatment mechanism for chronic pain but remains untested in clinical populations. Two interlinked studies; (1) A patient-assessor blinded, randomised, sham-controlled clinical trial and (2) an open-label mechanist...

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Bibliographic Details
Main Authors: Selina Johnson, Anne Marshall, Dyfrig Hughes, Emily Holmes, Florian Henrich, Turo Nurmikko, Manohar Sharma, Bernhard Frank, Paul Bassett, Andrew Marshall, Walter Magerl, Andreas Goebel
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Journal of Translational Medicine
Subjects:
Peripheral nerve stimulation
Peripheral neuropathic pain
Long term depression
Chronic pain
Low frequency
Online Access:https://doi.org/10.1186/s12967-021-03128-2

Internet

https://doi.org/10.1186/s12967-021-03128-2

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