Structures of two aptamers with differing ligand specificity reveal ruggedness in the functional landscape of RNA

Structures of two aptamers with differing ligand specificity reveal ruggedness in the functional landscape of RNA

Two classes of riboswitches related to the ykkC guanidine-I riboswitch bind phosphoribosyl pyrophosphate (PRPP) and guanosine tetraphosphate (ppGpp). Here we report the co-crystal structure of the PRPP aptamer and its ligand. We also report the structure of the G96A point mutant that prefers ppGpp o...

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Bibliographic Details
Main Authors: Andrew John Knappenberger, Caroline Wetherington Reiss, Scott A Strobel
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-06-01
Series:eLife
Subjects:
RNA structure
riboswitch
ykkC
PRPP
ppGpp
Online Access:https://elifesciences.org/articles/36381

Internet

https://elifesciences.org/articles/36381

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