Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy

Ryanodine receptor dysfunction causes senescence and fibrosis in Duchenne dilated cardiomyopathy

Abstract Background Duchenne muscular dystrophy (DMD) is an X‐linked disorder characterized by progressive muscle weakness due to the absence of functional dystrophin. DMD patients also develop dilated cardiomyopathy (DCM). We have previously shown that DMD (mdx) mice and a canine DMD model (GRMD) e...

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Bibliographic Details
Main Authors: Monia Souidi, Jessica Resta, Haikel Dridi, Yvonne Sleiman, Steve Reiken, Karina Formoso, Sarah Colombani, Pascal Amédro, Pierre Meyer, Azzouz Charrabi, Marie Vincenti, Yang Liu, Rajesh Kumar Soni, Frank Lezoualc'h, D.V.M. Stéphane Blot, François Rivier, Olivier Cazorla, Angelo Parini, Andrew R. Marks, Jeanne Mialet‐Perez, Alain Lacampagne, Albano C. Meli
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Calcium
DMD
hiPSC‐derived cardiomyocytes
Ryanodine receptor
Senescence
Online Access:https://doi.org/10.1002/jcsm.13411

Internet

https://doi.org/10.1002/jcsm.13411

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