Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1

Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1

STX4 is a regulator of the glucose transporter GLUT4 vesicle fusion at the plasma membrane in skeletal muscle. Here, the authors show that skeletal muscle-specific STX4 enrichment reverses established insulin resistance and improves mitochondrial function in the context of diabetogenic stress.

Bibliographic Details
Main Authors: Karla E. Merz, Jinhee Hwang, Chunxue Zhou, Rajakrishnan Veluthakal, Erika M. McCown, Angelica Hamilton, Eunjin Oh, Wenting Dai, Patrick T. Fueger, Lei Jiang, Janice. M. Huss, Debbie C. Thurmond
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28061-w

Internet

https://doi.org/10.1038/s41467-022-28061-w

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