Increased serum level of alpha-2 macroglobulin and its production by B-lymphocytes in chronic lymphocytic leukemia

Increased serum level of alpha-2 macroglobulin and its production by B-lymphocytes in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL), the most common adult’s leukemia in the western world, is caused in 95% of the cases by uncontrolled proliferation of monoclonal B-lymphocytes. The complement system in CLL is chronically activated at a low level via the classical pathway (CP). This chronic activa...

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Bibliographic Details
Main Authors: Regina Michelis, Lama Milhem, Evleen Galouk, Galia Stemer, Ariel Aviv, Tamar Tadmor, Mona Shehadeh, Lev Shvidel, Masad Barhoum, Andrei Braester
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
alpha-2-macroglobulin (A2M)
B-lymphocytes
chronic lymphocytic leukemia
complement system
classical pathway of complement
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.953644/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.953644/full

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