RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells

RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells

Summary: Overexpression of Cyclin E1 perturbs DNA replication, resulting in DNA lesions and genomic instability. Consequently, Cyclin E1-overexpressing cancer cells increasingly rely on DNA repair, including RAD52-mediated break-induced replication during interphase. We show that not all DNA lesions...

Full description

Bibliographic Details
Main Authors: Anastasia Audrey, Yannick P. Kok, Shibo Yu, Lauren de Haan, Bert van de Kooij, Nathalie van den Tempel, Mengting Chen, H. Rudolf de Boer, Bert van der Vegt, Marcel A.T.M. van Vugt
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Cell Reports
Subjects:
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724004443

Internet

http://www.sciencedirect.com/science/article/pii/S2211124724004443

Similar Items