Formononetin Ameliorates Renal Dysfunction, Oxidative Stress, Inflammation, and Apoptosis and Upregulates Nrf2/HO-1 Signaling in a Rat Model of Gentamicin-Induced Nephrotoxicity

Formononetin Ameliorates Renal Dysfunction, Oxidative Stress, Inflammation, and Apoptosis and Upregulates Nrf2/HO-1 Signaling in a Rat Model of Gentamicin-Induced Nephrotoxicity

Gentamicin (GEN) is a bactericidal aminoglycoside known to cause nephrotoxicity. Formononetin (FN) is a potent flavonoid that exhibits numerous promising pharmacological activities. In this study, we have assessed the nephroprotective efficacy of FN against GEN-induced renal injury in rats. Rats wer...

Full description

Bibliographic Details
Main Authors: Osama Y. Althunibat, Mohammad H. Abukhalil, Saleem H. Aladaileh, Haitham Qaralleh, Wesam Al-Amarat, Manal A. Alfwuaires, Abdulmohsen I. Algefare, Nader Ibrahim Namazi, Sahar J. Melebary, Ahmad O. Babalghith, Carlos Adam Conte-Junior
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
formononetin
gentamicin
nephrotoxicity
inflammation
oxidative stress
Nrf2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.916732/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.916732/full

Similar Items