Administration of a TLR9 Inhibitor Attenuates the Development and Progression of Heart Failure in Mice

Administration of a TLR9 Inhibitor Attenuates the Development and Progression of Heart Failure in Mice

Summary: Mitochondrial deoxyribonucleic acid, containing the unmethylated cytidine-phosphate-guanosine motif, stimulates Toll-like receptor 9 to induce inflammation and heart failure. A small chemical, E6446 [(6-[3-(pyrrolidin-1-yl)propoxy)-2-(4-(3-(pyrrolidin-1-yl)propoxy)phenyl]benzo[d]oxazole)],...

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Main Authors: Hiromichi Ueda, MD, Osamu Yamaguchi, MD, PhD, Manabu Taneike, MD, PhD, Yasuhiro Akazawa, MD, Haruko Wada-Kobayashi, MD, Ryuta Sugihara, MD, Hiroki Yorifuji, MD, Hiroyuki Nakayama, MD, PhD, Shigemiki Omiya, MD, PhD, Tomokazu Murakawa, MD, PhD, Yasushi Sakata, MD, PhD, Kinya Otsu, MD, PhD
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X19300099

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http://www.sciencedirect.com/science/article/pii/S2452302X19300099

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