Design of D-Amino Acids SARS-CoV-2 Main Protease Inhibitors Using the Cationic Peptide from Rattlesnake Venom as a Scaffold

Design of D-Amino Acids SARS-CoV-2 Main Protease Inhibitors Using the Cationic Peptide from Rattlesnake Venom as a Scaffold

The C30 endopeptidase (3C-like protease; 3CL<sup>pro</sup>) is essential for the life cycle of SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) since it plays a pivotal role in viral replication and transcription and, hence, is a promising drug target. Molecules isolated from...

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Bibliographic Details
Main Authors: Raphael J. Eberle, Ian Gering, Markus Tusche, Philipp N. Ostermann, Lisa Müller, Ortwin Adams, Heiner Schaal, Danilo S. Olivier, Marcos S. Amaral, Raghuvir K. Arni, Dieter Willbold, Mônika A. Coronado
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceuticals
Subjects:
SARS-CoV-2
COVID-19
3CL<sup>pro</sup>
main protease
inhibitor
crotamine derivative peptides
Online Access:https://www.mdpi.com/1424-8247/15/5/540

Internet

https://www.mdpi.com/1424-8247/15/5/540

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