Risk factors associated with Streptococcus pneumonia carriage in children under five years old with acute respiratory infection in Niger
INTRODUCTION : streptococcus pneumonia is a leading cause of bacterial pneumonia, meningitis and sepsis in children, and pneumococcal carriage is an important source of horizontal spread of these pathogens within the community.Methods: a questionnaire was addressed to parents for the collection of s...
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The Pan African Medical Journal
2019-07-01
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https://www.panafrican-med-journal.com/content/article/33/239/pdf/239.pdf
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author | Ibrahim Dan Dano Sani Ousmane Kamaye Moumouni Adamou Lagare Idi Issa Jean Testa |
author_facet | Ibrahim Dan Dano Sani Ousmane Kamaye Moumouni Adamou Lagare Idi Issa Jean Testa |
author_sort | Ibrahim Dan Dano |
collection | DOAJ |
description | INTRODUCTION : streptococcus pneumonia is a leading cause of bacterial pneumonia, meningitis and sepsis in children, and pneumococcal carriage is an important source of horizontal spread of these pathogens within the community.Methods: a questionnaire was addressed to parents for the collection of sociodemographic and medical information. Nasopharyngeal swabbing was processed using a molecular method. We used logistic regression models to examine independent associations between pneumococcal carriage and potential risk factors. All associations with a p-value of 0.25 in the bivariate regression analyses were subsequently entered in the multivariate regression model.Results: a total of 637 children aged 1 to 59 months admitted for acute respiratory infection were included. The rate of respiratory virus carriage was 76%, whereas that of bacteria was 47% and that of bacteria-virus co-colonization was 42%. A bivariate analysis showed that carriage was not related to gender, father's or mother's education level, father's occupation, type of housing or lighting, or passive exposure to cigarette smoking in the house. It was also not linked to complete vaccination with PCV-13 or PPSV-23 and antibiotic treatment prior to hospitalization. A multivariate analysis showed that carriage was related to age greater than 3 months, maternal occupation, house flooring type, and co-colonization of another bacterium and virus.Conclusion: these results can be helpful to understand the dynamics of pneumococcal nasopharyngeal colonization; they confirm the interest of vaccinating infants before the age of 3 months with appropriate vaccine to prevent spread nasopharyngeal colonization and pneumococcal diseases in children. |
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issn | 1937-8688 1937-8688 |
language | English |
last_indexed | 2024-12-10T21:00:56Z |
publishDate | 2019-07-01 |
publisher | The Pan African Medical Journal |
record_format | Article |
series | The Pan African Medical Journal |
spelling | doaj.art-86e1de6223be42caa69787953e0e39312022-12-22T01:33:49ZengThe Pan African Medical JournalThe Pan African Medical Journal1937-86881937-86882019-07-013323910.11604/pamj.2019.33.239.1594515945Risk factors associated with Streptococcus pneumonia carriage in children under five years old with acute respiratory infection in NigerIbrahim Dan Dano0Sani Ousmane1Kamaye Moumouni2Adamou Lagare3Idi Issa4Jean Testa5 Centre de Recherche Médicale et Sanitaire (CERMES), 634 Boulevard de la Nation, Niamey, Niger Centre de Recherche Médicale et Sanitaire (CERMES), 634 Boulevard de la Nation, Niamey, Niger Hôpital National de Niamey (HNN), Service de Pédiatrie A, Niamey, Niger Centre de Recherche Médicale et Sanitaire (CERMES), 634 Boulevard de la Nation, Niamey, Niger Centre de Recherche Médicale et Sanitaire (CERMES), 634 Boulevard de la Nation, Niamey, Niger Centre de Recherche Médicale et Sanitaire (CERMES), 634 Boulevard de la Nation, Niamey, Niger INTRODUCTION : streptococcus pneumonia is a leading cause of bacterial pneumonia, meningitis and sepsis in children, and pneumococcal carriage is an important source of horizontal spread of these pathogens within the community.Methods: a questionnaire was addressed to parents for the collection of sociodemographic and medical information. Nasopharyngeal swabbing was processed using a molecular method. We used logistic regression models to examine independent associations between pneumococcal carriage and potential risk factors. All associations with a p-value of 0.25 in the bivariate regression analyses were subsequently entered in the multivariate regression model.Results: a total of 637 children aged 1 to 59 months admitted for acute respiratory infection were included. The rate of respiratory virus carriage was 76%, whereas that of bacteria was 47% and that of bacteria-virus co-colonization was 42%. A bivariate analysis showed that carriage was not related to gender, father's or mother's education level, father's occupation, type of housing or lighting, or passive exposure to cigarette smoking in the house. It was also not linked to complete vaccination with PCV-13 or PPSV-23 and antibiotic treatment prior to hospitalization. A multivariate analysis showed that carriage was related to age greater than 3 months, maternal occupation, house flooring type, and co-colonization of another bacterium and virus.Conclusion: these results can be helpful to understand the dynamics of pneumococcal nasopharyngeal colonization; they confirm the interest of vaccinating infants before the age of 3 months with appropriate vaccine to prevent spread nasopharyngeal colonization and pneumococcal diseases in children. https://www.panafrican-med-journal.com/content/article/33/239/pdf/239.pdf risk factorsnasopharyngeal carriagepneumoniachildren under five years |
spellingShingle | Ibrahim Dan Dano Sani Ousmane Kamaye Moumouni Adamou Lagare Idi Issa Jean Testa Risk factors associated with Streptococcus pneumonia carriage in children under five years old with acute respiratory infection in Niger The Pan African Medical Journal risk factors nasopharyngeal carriage pneumoniachildren under five years |
title | Risk factors associated with Streptococcus pneumonia carriage in children under five years old with acute respiratory infection in Niger |
title_full | Risk factors associated with Streptococcus pneumonia carriage in children under five years old with acute respiratory infection in Niger |
title_fullStr | Risk factors associated with Streptococcus pneumonia carriage in children under five years old with acute respiratory infection in Niger |
title_full_unstemmed | Risk factors associated with Streptococcus pneumonia carriage in children under five years old with acute respiratory infection in Niger |
title_short | Risk factors associated with Streptococcus pneumonia carriage in children under five years old with acute respiratory infection in Niger |
title_sort | risk factors associated with streptococcus pneumonia carriage in children under five years old with acute respiratory infection in niger |
topic | risk factors nasopharyngeal carriage pneumoniachildren under five years |
url |
https://www.panafrican-med-journal.com/content/article/33/239/pdf/239.pdf
|
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