Risk factors associated with Streptococcus pneumonia carriage in children under five years old with acute respiratory infection in Niger

INTRODUCTION : streptococcus pneumonia is a leading cause of bacterial pneumonia, meningitis and sepsis in children, and pneumococcal carriage is an important source of horizontal spread of these pathogens within the community.Methods: a questionnaire was addressed to parents for the collection of s...

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Main Authors: Ibrahim Dan Dano, Sani Ousmane, Kamaye Moumouni, Adamou Lagare, Idi Issa, Jean Testa
Format: Article
Language:English
Published: The Pan African Medical Journal 2019-07-01
Series:The Pan African Medical Journal
Subjects:
Online Access: https://www.panafrican-med-journal.com/content/article/33/239/pdf/239.pdf
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author Ibrahim Dan Dano
Sani Ousmane
Kamaye Moumouni
Adamou Lagare
Idi Issa
Jean Testa
author_facet Ibrahim Dan Dano
Sani Ousmane
Kamaye Moumouni
Adamou Lagare
Idi Issa
Jean Testa
author_sort Ibrahim Dan Dano
collection DOAJ
description INTRODUCTION : streptococcus pneumonia is a leading cause of bacterial pneumonia, meningitis and sepsis in children, and pneumococcal carriage is an important source of horizontal spread of these pathogens within the community.Methods: a questionnaire was addressed to parents for the collection of sociodemographic and medical information. Nasopharyngeal swabbing was processed using a molecular method. We used logistic regression models to examine independent associations between pneumococcal carriage and potential risk factors. All associations with a p-value of 0.25 in the bivariate regression analyses were subsequently entered in the multivariate regression model.Results: a total of 637 children aged 1 to 59 months admitted for acute respiratory infection were included. The rate of respiratory virus carriage was 76%, whereas that of bacteria was 47% and that of bacteria-virus co-colonization was 42%. A bivariate analysis showed that carriage was not related to gender, father's or mother's education level, father's occupation, type of housing or lighting, or passive exposure to cigarette smoking in the house. It was also not linked to complete vaccination with PCV-13 or PPSV-23 and antibiotic treatment prior to hospitalization. A multivariate analysis showed that carriage was related to age greater than 3 months, maternal occupation, house flooring type, and co-colonization of another bacterium and virus.Conclusion: these results can be helpful to understand the dynamics of pneumococcal nasopharyngeal colonization; they confirm the interest of vaccinating infants before the age of 3 months with appropriate vaccine to prevent spread nasopharyngeal colonization and pneumococcal diseases in children.
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spelling doaj.art-86e1de6223be42caa69787953e0e39312022-12-22T01:33:49ZengThe Pan African Medical JournalThe Pan African Medical Journal1937-86881937-86882019-07-013323910.11604/pamj.2019.33.239.1594515945Risk factors associated with Streptococcus pneumonia carriage in children under five years old with acute respiratory infection in NigerIbrahim Dan Dano0Sani Ousmane1Kamaye Moumouni2Adamou Lagare3Idi Issa4Jean Testa5 Centre de Recherche Médicale et Sanitaire (CERMES), 634 Boulevard de la Nation, Niamey, Niger Centre de Recherche Médicale et Sanitaire (CERMES), 634 Boulevard de la Nation, Niamey, Niger Hôpital National de Niamey (HNN), Service de Pédiatrie A, Niamey, Niger Centre de Recherche Médicale et Sanitaire (CERMES), 634 Boulevard de la Nation, Niamey, Niger Centre de Recherche Médicale et Sanitaire (CERMES), 634 Boulevard de la Nation, Niamey, Niger Centre de Recherche Médicale et Sanitaire (CERMES), 634 Boulevard de la Nation, Niamey, Niger INTRODUCTION : streptococcus pneumonia is a leading cause of bacterial pneumonia, meningitis and sepsis in children, and pneumococcal carriage is an important source of horizontal spread of these pathogens within the community.Methods: a questionnaire was addressed to parents for the collection of sociodemographic and medical information. Nasopharyngeal swabbing was processed using a molecular method. We used logistic regression models to examine independent associations between pneumococcal carriage and potential risk factors. All associations with a p-value of 0.25 in the bivariate regression analyses were subsequently entered in the multivariate regression model.Results: a total of 637 children aged 1 to 59 months admitted for acute respiratory infection were included. The rate of respiratory virus carriage was 76%, whereas that of bacteria was 47% and that of bacteria-virus co-colonization was 42%. A bivariate analysis showed that carriage was not related to gender, father's or mother's education level, father's occupation, type of housing or lighting, or passive exposure to cigarette smoking in the house. It was also not linked to complete vaccination with PCV-13 or PPSV-23 and antibiotic treatment prior to hospitalization. A multivariate analysis showed that carriage was related to age greater than 3 months, maternal occupation, house flooring type, and co-colonization of another bacterium and virus.Conclusion: these results can be helpful to understand the dynamics of pneumococcal nasopharyngeal colonization; they confirm the interest of vaccinating infants before the age of 3 months with appropriate vaccine to prevent spread nasopharyngeal colonization and pneumococcal diseases in children. https://www.panafrican-med-journal.com/content/article/33/239/pdf/239.pdf risk factorsnasopharyngeal carriagepneumoniachildren under five years
spellingShingle Ibrahim Dan Dano
Sani Ousmane
Kamaye Moumouni
Adamou Lagare
Idi Issa
Jean Testa
Risk factors associated with Streptococcus pneumonia carriage in children under five years old with acute respiratory infection in Niger
The Pan African Medical Journal
risk factors
nasopharyngeal carriage
pneumoniachildren under five years
title Risk factors associated with Streptococcus pneumonia carriage in children under five years old with acute respiratory infection in Niger
title_full Risk factors associated with Streptococcus pneumonia carriage in children under five years old with acute respiratory infection in Niger
title_fullStr Risk factors associated with Streptococcus pneumonia carriage in children under five years old with acute respiratory infection in Niger
title_full_unstemmed Risk factors associated with Streptococcus pneumonia carriage in children under five years old with acute respiratory infection in Niger
title_short Risk factors associated with Streptococcus pneumonia carriage in children under five years old with acute respiratory infection in Niger
title_sort risk factors associated with streptococcus pneumonia carriage in children under five years old with acute respiratory infection in niger
topic risk factors
nasopharyngeal carriage
pneumoniachildren under five years
url https://www.panafrican-med-journal.com/content/article/33/239/pdf/239.pdf
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