N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway

N6-methyladenosine-mediated SH3BP5-AS1 upregulation promotes GEM chemoresistance in pancreatic cancer by activating the Wnt signaling pathway

Abstract Background Pancreatic cancer (PC) is highly malignant. Chemotherapy is the main treatment strategy, especially for patients with advanced PC. However, chemoresistance has always been a frequently encountered bottleneck. Hence, there is an urgent need to enhance the sensitivity of PC to gemc...

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Bibliographic Details
Main Authors: Chengjie Lin, Yan Wang, Yihong Dong, Shihui Lai, Liang Wang, Shangeng Weng, Xiang Zhang
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Biology Direct
Subjects:
SH3BP5-AS1
N6-methyladenosine
Pancreatic cancer
Chemoresistance
Wnt signaling pathway
Online Access:https://doi.org/10.1186/s13062-022-00347-5

Internet

https://doi.org/10.1186/s13062-022-00347-5

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