Near-digital amplification in paper improves sensitivity and speed in biplexed reactions

Abstract The simplest point-of-care assays are usually paper and plastic devices that detect proteins or nucleic acids at low cost and minimal user steps, albeit with poor limits of detection. Digital assays improve limits of detection and analyte quantification by splitting a sample across many wel...

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Bibliographic Details
Main Authors: Kamal G. Shah, Sujatha Kumar, Paul Yager
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-18937-8